Clever Lab

Supramolecular Coordination Chemistry

Clever Lab

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Research Interests:

Chemistry inside Molecular Cages:


Molecular cages and capsules provide nanoscopic environments which can be used as the smallest imaginable reaction flasks. Immobilization of catalytically active entities such as transition metals inside these engineered cavities is envisioned to lead to a promising new class of catalysts on the long way to artificial systems with enzyme-like substrate specificity, selectivity and turn-over.
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DNA-Supramolecular Hybrid Structures:


In recent years, DNA has become popular as a programmable building material in bottom-up nanotechnology. DNA origami and Metal DNA are prominent examples. In combination with the various techniques of the supramolecular chemistry toolbox (host-guest binding, metal-coordination, aggregation of amphiphilic residues...) new functional systems with a focus on nano-mechanical devices are being developed.
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Publications & Other Activities:



Peer Reviewed Papers, Contributions to books:

2014

"Self-Assembled Coordination Cages based on Banana-shaped Ligands"
M. Han, D. M. Engelhard, G. H. Clever, Chem. Soc. Rev. 2014, 43, 1848.

"Narcissistic self-sorting vs. statistic ligand shuffling within a series of phenothiazine-based coordination cages"
M. Frank, L. Krause, R. Herbst-Irmer, D. Stalke, G. H. Clever, Dalton Trans. 2014, DOI:10.1039/C3DT53243G.


"Rational Design of a Face-Centred Square-Cuboid Coordination Cage"
M. Han, R. Michel, G. H. Clever, Chem. Eur. J. 2014, DOI: 10.1002/chem.201303181.


2013

"Reversible Stabilization of Transition Metal-binding DNA G-Quadruplexes"
D. M. Engelhard, R. Pievo, G. H. Clever, Angew. Chem. Int. Ed. 2013, 52, 12843.


"Relative Anion Binding Affinity in a Series of Interpenetrated Coordination Cages"
M. Frank, J. M. Dieterich, S. Freye, R. A. Mata, G. H. Clever, Dalton Trans. 2013, 42, 15906.

"The rapid, solvent-free, synthesis of pyridyl-functionalised [5]polynorbornane-based ligands for metal-organic rings and cages"
M. D. Johnstone, M. Frank, G. H. Clever, F. M. Pfeffer, Eur. J. Org. Chem. 2013, 26, 5848.

"Assembly and Stepwise Oxidation of Interpenetrated Coordination Cages based on Phenothiazine"
M. Frank, J. Hey, I. Balcioglu, Y.-S. Chen, D. Stalke, T. Suenobu, S. Fukuzumi, H. Frauendorf, G. H. Clever, Angew. Chem. Int. Ed. 2013, 52, 10102.

"Template Control over Dimerization and Guest Selectivity of Interpenetrated Coordination Cages"
S. Freye, R. Michel, D. Stalke, M. Pawliczek, H. Frauendorf, G. H. Clever, J. Am. Chem. Soc. 2013, 135, 8476.
(Highlighted in the ACS Virtual Issue on "Synthetic Inorganic Chemistry" 2013).

"Stable and Metastable Self-Assembled Rings based on trans-chelated Pd(II)"
F. A. Pereira, T. Fallows, M. Frank, A. Chen, G. H. Clever, Z. Anorg. Allg. Chem. 2013, 639, 1598–1605.


"Counter Ion Dynamics in an Interpenetrated Coordination Cage Capable of Dissolving AgCl"
S. Freye, D. M. Engelhard, M. John, G. H. Clever, Chem. Eur. J. 2013, 19, 2114.

"Light-triggered Guest Uptake and Release by a Photochromic Coordination Cage"
M. Han, R. Michel, B. He, Y.-S. Chen, D. Stalke, M. John, G. H. Clever, Angew. Chem. Int. Ed. 2013, 52, 1319. ("Hot Paper")

"Artificial DNA directed toward synthetic Metallo-Foldamers"
G. H. Clever and M. Shionoya, in "Metallofoldamers: Supramolecular Architectures from Helicates to Biomimetics" G. Maayan, M Albrecht (Eds.), Wiley-VCH, Weinheim, 2013, ISBN: 978-0-470-97323-3


2012

"An Inclusion Complex of Hexamolybdate inside a Supramolecular Cage and its Structural Conversion"
M. Han, J. Hey, W. Kawamura, D. Stalke, M. Shionoya, G. H. Clever, Inorg. Chem. 2012, 51, 9574.
(Highlighted in the ACS Virtual Issue on "Synthetic Inorganic Chemistry" 2013).


"A push-and-pull model for allosteric anion binding in cage complexes"
J. M. Dieterich, G. H. Clever, R. A. Mata, Phys. Chem. Chem. Phys. 2012, 14, 12746.

"NMR-Based Structure Determination of an Intertwined Coordination Cage resembling a Double Trefoil Knot"
D. M. Engelhard, S. Freye, K. Grohe, M. John, G. H. Clever, Angew. Chem. Int. Ed. 2012, 51, 4747.

"Magnus’ Salt-type Stacked Platinum Complexes inside a Coordination Cage"
G. H. Clever, W. Kawamura, S. Tashiro, M. Shiro, M. Shionoya, Angew. Chem. Int. Ed. 2012, 51, 2606.
(Inside cover picture, "Hot Paper")

"Allosteric Binding of Halide Anions by a New Dimeric Interpenetrated Coordination Cage"
S. Freye, J. Hey, A. Torras-Galán, D. Stalke, R. Herbst-Irmer, M. John, G. H. Clever, Angew. Chem. Int. Ed. 2012, 51, 2191.

"Switchable host-guest interactions of supramolecular rings and cages"
G. H. Clever in "Molecules at Work", B. Pignataro (Ed.); Wiley-VCH, 2012, ISBN-13: 978-3-527-33093-5.

"Alternative DNA base pairing through metal coordination"
G. H. Clever and M. Shionoya, in "Interplay between Metal Ions and Nucleic Acids", Vol. 10 of 'Metal Ions in Life Sciences', A. Sigel, H. Sigel, R. K. O. Sigel (Eds.); Springer Science + Business Media B.V., Dordrecht, 2012.

2011

"Direct Conductance Measurement of Individual Metallo-DNA Duplexes within Single-Molecule Break Junctions"
S. Liu, G. H. Clever, Y. Takezawa, M. Kaneko, K. Tanaka, X. Guo, M. Shionoya, Angew. Chem. Int. Ed. 2011, 50, 8886.
(Inside cover picture)
Highlighted in NPG Asia Materials (Nature Publishing Group)

"Encapsulation vs. Aggregation of Metal-Organic Cages Controlled by Guest Size Variation"
G. H. Clever, W. Kawamura, M. Shionoya, Inorg. Chem. 2011, 50, 4689.

2010

"A pH Switchable Pseudorotaxane based on a Metal Cage and a Bis-Anionic Thread"
G. H. Clever, M. Shionoya, Chem. Eur. J. 2010, 16, 11792.
(Inside cover picture)


"Light-Triggered Crystallization of a Molecular Host-Guest Complex"
G. H. Clever, S. Tashiro, M. Shionoya, J. Am. Chem. Soc. 2010, 132, 9973.

"Anti-ferromagnetic Coupling of stacked Cu(II) Salen Complexes in DNA"
G. H. Clever, S. J. Reitmeier, T. Carell, O. Schiemann, Angew. Chem. Int. Ed. 2010, 49, 4927.

"Metal-base pairing in DNA"
G. H. Clever, M. Shionoya, Coord. Chem. Rev. 2010, 254, 2391.

2009

“Inclusion of Anionic Guests inside a Molecular Cage with Pd-Centers as Electrostatic Anchors”
G. H. Clever, S. Tashiro, M. Shionoya, Angew. Chem. Int. Ed. 2009, 48, 7010.

2008

“Chain-like Assembly of Gold Nanoparticles on Artificial DNA Templates via Click Chemistry”
M. Fischler, A. Sologubenko, J. Mayer, G. Clever, G. Burley, J. Gierlich, T. Carell, U. Simon, Chem. Comm. 2008, 169.
(Highlighted in Chem. Sci. 2008, 5, C12)

2007

“DNA-Metal Base Pairs”
G. H. Clever, C. Kaul, T. Carell, Angew. Chem. Int. Ed. 2007, 46, 6226.

“Controlled Stacking of 10 Transition Metal Ions inside a DNA Duplex”
G. H. Clever, T. Carell, Angew. Chem. Int. Ed. 2007, 46, 250.

2006

“Programmable Self-Assembly of Metal Ions inside Artificial DNA Duplexes“
K. Tanaka, G. H. Clever, Y. Takezawa, Y. Yamada, C. Kaul, M. Shionoya, T. Carell, Nat. Nanotech. 2006, 1, 190.
(Highlighted in Nature 2006, 444, 698)

“Metal-Salen-Base-Pair Complexes Inside DNA: Complexation Overrides Sequence Information“
G. H. Clever, Y. Söltl, H. Burks, W. Spahl, T. Carell, Chem. Eur. J. 2006, 12, 8708.

2005

“A Highly DNA-Duplex-Stabilizing Metal-Salen Base Pair”
G. H. Clever, K. Polborn, T. Carell, Angew. Chem. Int. Ed. 2005, 44, 7204.

Others:

"Trendberichte Anorganische Chemie 2012 - Supramolekulare Koordinationschemie"
Guido H. Clever, Nachrichten aus der Chemie, 2013, 3, 239.

"Japanese-German Symposium on Coordination Programming"
G. H. Clever, Nachrichten aus der Chemie, 2013, 61, _.

"Trendberichte Anorganische Chemie 2011 - Supramolekulare Koordinationschemie"
Guido H. Clever, Nachrichten aus der Chemie, 2012, 3, 216.

"DNA in a modern world" (Editorial)
Eugen Stulz, Guido Clever, Mitsuhiko Shionoya, Chengde Mao, Chem. Soc. Rev., 2011, DOI: 10.1039/C1CS90048J.

“Genetischer Code auf Basis von Metallionen”
G. H. Clever, C. Kaul, T. Carell, Bioforum 2007, 30, 22.

“3rd International Symposium of the Volkswagen Foundation: Complex Materials”
G. H. Clever, K. Gutsmiedl, C. Kaul, C. Wirges, Small 2007,3, 922.

“Assembly of a Highly DNA-Duplex-Stabilizing Metal-Salen Base Pair”
G. H. Clever, T. Carell, Coll. Symp. Ser. (M. Hocek, Ed.), Vol 7, p. 389 - 391. Institute of Org. Chem and Biochem., Academy Of Sciences of the Czech Republic, Prague 2005.

Conference Contributions:

Poster presentations on ACS-YCC meeting, Boston 2001, JCF meeting, Heidelberg 2004 (poster prize), ORCHEM, Bad Nauheim 2004, Nanobionics III, Marburg 2005, NAC XIII, Prague 2005, Summer School FrontChem, Tokyo 2006, Int. COE Symposium, Tokyo 2006,
1. Asian Conf. on Coord. Chem., Okazaki 2007, 18th Symposium on Role of Metals in Biol. React., Biol. and Med. (SRM2008), Nagoya 2008 (poster prize), 4th EuChemS Conference on Nitrogen Ligands, Garmisch-Partenkirchen 2008, DNAtec 09, Dresden 2009, ISPPCC, Sapporo 2009, Wöhler Tagung Freiburg, 2010, ISMSC Brighton 2011, SupraChem Münster 2013, Bürgenstock Conference Brunnen 2013.

Oral presentation on Volkswagen Foundation meeting, Aachen 2005.
Oral presentation on “Roche Symposium for Leading Scientists of the next decade”, Basel 2005.
Oral presentation on FCI stipend meeting, Munich 2006.
Oral presentation in the Seminar of SFB 624 (From the Design of Chemical Templates towards Reaction Control), Kekulé Institut, Bonn University 2008.
Oral presentation in the Center of Nanoscale Science and Technology, Peking University 2008.
Oral presentation in the Org. Chem. Colloquium, Düsseldorf University 2009.
Oral presentation at the Annual Meeting of the Chemical Society of Japan (Nenkai), Funabashi 2009.
Oral presentation at the 5. Host-Guest Symposium, Utsunomiya 2009.
Oral presentation in the Zesty Seminar, Tokyo University 2009.
Invited Talk at the “14th International Conference on Biological Inorganic Chemistry” (ICBIC14), Nagoya 2009.
Lecture trip Germany/UK 2010 giving oral presentations at the Universities of Heidelberg, Aachen, Münster, Southampton, Edinburgh and St. Andrews (supported by the Young Researchers Startup Grant, JSPS).
Oral presentation at the "Japanese-German University Presidents’ Conference" (HeKKSaGon), Heidelberg, 2010.
Oral presentation in the Dept. of Chemistry, Cambridge University, UK, 2010.
Oral presentations at EuChemMS, Nürnberg, 2010.
Lecture at the Chemical Resources Laboratory, Tokyo Institute of Technology, 2010.
Lecture at the Dept. Chem. Engineering, Tokyo University, 2010.
Oral presentation at the Bioorganic Chemistry Symposium, Göttingen, 2010.
Oral presentation at the IRTG 1422 Workshop, Lund, Sweden, 2011.
Oral presentation at the SupraChem 2011 Conference, Essen, 2011.
Oral presentation at the Koordinationschemietreffen Stuttgart, 2011.
Oral presentation at the Chemiedozententagung Mainz, 2011.
Oral presentation at the International Symposium on Macrocyclic and Supramolecular Chemistry (ISMSC), Brighton, UK, 2011.
Lecture trip Japan 2011 (JSPS Bridge Fellowship) giving oral presentations at the "61. Symposium of the Japanese Society for Coordination Chemistry", Okayama (2x), Ritsumeikan University (Kyoto), Osaka University, Nagasaki University, Tokyo Institute of Technology, Ochanomizu University (Tokyo), Tokyo University and Nagoya University (guest speaker of the Muenster-Nagoya IRTG meeting).
Oral Presentation at the JSPS meeting, Senckenberg Museum, Frankfurt a. M., 2011.
Oral presentation at the "Japan Tage der Georg-August Universität Göttingen", 2011.
Oral presentation at the Organic Chemistry Colloquium, Ulm University, 2011.
Oral presentation at the Weihnachtskolloquium, Göttingen University, 2011.
Oral presentation at the Inorganic Chemistry Colloquium, RWTH Aachen, 2012.
Oral presentation at the Chemiedozententagung Freiburg, 2012.
Oral presentation at the "Japanese-German University Presidents’ Conference" (HeKKSaGon), Kyoto, 2012.
Oral and poster presentation at the Alexander von Humboldt Foundation's 5th Sino-German Frontiers of Science (SinoGFOS) symposium, Nanjing, China, 2012.
Lecture trip China 2012 giving oral presentations at Fudan University (Shanghai), East China Normal University (Shanghai), Zhejiang University (Hangzhou), Nanjing University (Nanjing) and Nanjing University of Technology (Nanjing).
Oral presentation at the Chemistry Colloquium, TU Braunschweig, 2012.
Oral presentation at the BuilMoNa Graduate School workshop, Leipzig University, 2012.
Oral presentation at the SFB 858 (Cooperative Effects) workshop, Münster University, 2012.
Oral presentation at the International Conference on Coordination Chemistry (ICCC), Valencia, 2012.
Oral presentation at the Japanese-German Symposium on Coordination Programming, Münster University, 2012.
Oral presentation at the Chemistry Colloquium, Köln University, 2012.
Oral presentation at the Chemistry Colloquium, Jacobs University Bremen, 2012.
Oral presentation at the Chemistry Colloquium, Siegen University, 2013.
Oral presentation at the Chemistry Colloquium, Oldenburg University, 2013.
Lecture trip Japan 2013 (HeKKSaGOn Network) giving oral presentations at Osaka University, Kyoto University, Kobe University, Tsukuba University and the University of Tokyo.
Two oral presentations at the Chemiedozententagung Berlin, 2013 (Receiving of the ADUC prize 2012).
Oral presentation at the Chemistry Colloquium, Kiel University, 2013.
Oral presentation at the International Symposium on Macrocyclic and Supramolecular Chemistry (ISMSC), Arlington, USA, 2013.
Oral presentation at the International Seminar on Inclusion Compounds (ISIC 14), Edinburgh, UK, 2013.
Oral presentation at the Centre for Systems Chemistry Symposium, Groningen, Netherlands, 2013.
Workshop organization and oral presentation at the 3rd HeKKSaGOn meeting, Göttingen, 2013.
Oral presentation at the Conjugates Oligomers and Polymers meeting (KOPO), Würzburg, 2013.
Oral presentation at the 3Met Conference, Karlsruhe Institute of Technology, 2013.
Oral presentation at Chemistry Colloquium, Cambridge University, 2013.
Workshop organization and oral presentation at the German Science Days Kyoto, 2013.
Oral presentation at Chemistry Colloquium, Kassel University, 2013.

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